منابع مشابه
An Unusual Phenomenon in Strychnine Convulsions
while to test the margin of safety claimed by the British Pharmacopoeia for the maximum dose of some of the toxic drugs ; amongst the many toxic substances that suggested themselves, strychnine was considered the safest, as the antidote is well known and its action almost quantitative. After consideration of all factors it was considered reasonable that I personally should become the subject of...
متن کاملPentylenetetrazol and strychnine convulsions in brain weight selected mice
The seizure sensitivities to pentylenetetrazol (Ptz, 25-100 mg/kg) and strychnine (S, 2 mg/kg) were tested in two mice lines selected for large (LB) and small (SB) brain weight (brain weight difference being approximately 75 mg). The selection was based on a regression line connecting body and brain weight. SB mice were more sensitive to both drugs-their seizure latencies were shorter and letha...
متن کاملStrychnine poisoning as an unusual cause of convulsions.
A fatal case of strychnine poisoning is presented. The patient vomited then suffered a series of tonic convulsions which were triggered by tactile stimulation. In between paroxysms he was initially alert. Eventually the patient became comatosed due to anoxia and had a cardiac arrest. He presented with a marked metabolic acidosis and rapidly developed renal failure caused by acute rhabdomyolysis...
متن کاملGlycine potentiates strychnine-induced convulsions: role of NMDA receptors.
Strychnine poisoning leads to seizures that have traditionally been attributed to competitive antagonism of glycine receptors in the spinal cord. Although glycine is thought to act as an inhibitory neurotransmitter, a strychnine-insensitive glycine (Gly2) receptor has been recently described in cultured mouse neurons that is thought to be allosterically linked to the excitatory amino acid NMDA ...
متن کاملThe Control of Strychnine Convulsions by Intraspinal Injections of Magnesium Sulphate
We feel that the results obtained in the human case and in our animal experiments justify the supposition that magnesium sulphate may be of use in controlling cases of poisoning by strychnine. It is a method easily available not only in large hospitals but in private practice, and requires no elaborate technique. The amount of magnesium sulphate to be used should follow the advice of Meltzer (1...
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ژورنال
عنوان ژورنال: Poultry Science
سال: 1976
ISSN: 0032-5791
DOI: 10.3382/ps.0551146